Leukocoria (white pupil)

Leukocoria (white pupil) can be seen in many different diseases.

One of those diseases is Coats disease. Coats disease is typically diagnosed in children and young adults, and it can present with a variety of symptoms, including decreased vision, strabismus (crossed eyes), and leukocoria (white pupil). Other NDP-related retinopathies include Norrie Disease, Familial Exudative Vitreoretinopathy (FEVR) and persistent hyperplastic primary vitreous (PHPV). Other diseases that can present with leukocoria include retinoblastoma (RB), Retinopathy of Prematurity (ROP), toxocariasis, congenital cataract, and coloboma. Therefore, it is important to consider a range of differential diagnoses when evaluating a patient with leukocoria.

Norrie Disease is an X-linked genetic disorder that primarily affects males. It can cause a range of ocular abnormalities, including retinal detachment, cataracts, and blindness. FEVR is an inherited disorder that affects the development of blood vessels in the retina. Like Coats disease, it can cause leakage and abnormal blood vessel growth, leading to vision loss.
Persistent Hyperplastic Primary Vitreous (PHPV) is a rare developmental disorder that affects the eye. It can cause a range of symptoms, including vision loss, strabismus, and leukocoria.

Retinoblastoma is a cancerous tumor that can develop in the retina, causing vision loss and other symptoms. ROP is a condition that primarily affects premature infants, and it can cause abnormal blood vessel growth in the retina. Toxocariasis is a parasitic infection that can cause inflammation and scarring in the eye, leading to vision loss. Congenital cataract is a condition that can cause clouding of the eye lens, leading to vision loss. Coloboma is a condition that causes a gap or hole in the eye structures, leading to vision loss.

In conclusion, there are many diseases that can present with leukocoria. It is important to consider a range of differential diagnoses when evaluating a patient with retinal disease.